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ASSOCIATION OF BORDETELLA PERTUSSIS ‐ INDUCED HYPERSENSITIVITY TO SEROTONIN WITH THE H‐2 GENE COMPLEX
Author(s) -
Teuscher C.
Publication year - 1986
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1986.tb01082.x
Subject(s) - bordetella pertussis , biology , congenic , haplotype , gene , sensitization , immunology , genetics , allele , microbiology and biotechnology , bacteria
SUMMARY Susceptibility to Bordetella pertussis‐induced sensitivity to serotonin was found to be associated with the H‐2 gene complex in mice. H‐2 congenic and independent strains which possess the H‐2 b and H‐2 s haplotypes were susceptible to serotonin sensitization by pertussigen (P‐HSF) while mice with the H‐2 k and H‐2 d haplotypes were resistant. The gene or genes which control susceptibility were found to map to the H‐2S b D b end of the H‐2 complex; susceptibility appears to be inherited as a co‐dominant trait. These findings indicate that HLA typing may be of value in predicting or interpreting possible adverse reactions to pertussis vaccine or infection in humans.