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MOLECULAR ANALYSIS OF A CASE OF IgA2 DEFICIENCY
Author(s) -
Oliviero S.,
DeMarchi M.,
Bast B. J. E. G.,
Zegers B. J. M.,
Van Loghem E.,
De Lange G.,
Carbonara O.
Publication year - 1986
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1986.tb01077.x
Subject(s) - gene , genetics , biology , genetic linkage , genetic analysis , serology , linkage (software) , microbiology and biotechnology , antibody
SUMMARY A family with two members with selective IgA2 deficiency was analysed by direct gene analysis with different probes for the IgCH region. No gross gene deletions or rearrangements were detected. Genetic analysis based on serological and molecular markers did not rule out linkage with the IgCH region. However, a defect of other genes not linked to the Ig heavy chain region and controlling the expression of IgA may be possible as well.