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TISSUE DISTRIBUTION OF THE PK ANTIGEN AS DETERMINED BY A MONOCLONAL ANTIBODY
Author(s) -
Kasai K.,
Galton J.,
Terasaki P. I.,
Wakisaka A.,
Kawahara M.,
Root T.,
Hakomori S. I.
Publication year - 1985
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1985.tb00848.x
Subject(s) - monoclonal antibody , biology , antigen , kidney , antibody , genitourinary system , stomach , microbiology and biotechnology , monoclonal , immunohistochemistry , immunology , endocrinology , anatomy , biochemistry
SUMMARY Using an anti‐P k monoclonal antibody (mAb) designated CPK‐1, the expression of the P k antigen was assessed on normal human tissue from non‐P k individuals. Although the P k antigen was detected on fibroblasts and blood vessels as previously reported, it was also found on smooth muscle cells of the digestive tract and the urogenital system. P k was also found on glandular cells of the stomach, oesophagus and prostate. Additionally, CPK‐1 reacted weakly with oesophagus squamous cells, and a small number of glomeruli and tubules in the kidney. The mechanism of expression of the P k determinant in non‐P k individuals is discussed.