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IMMUNOGLOBULIN ALLOTYPES IN PATIENTS IN END‐STAGE RENAL FAILURE
Author(s) -
Laundy G. J.,
Bradley B. A.
Publication year - 1985
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1985.tb00845.x
Subject(s) - allotype , haplotype , glomerulonephritis , urinary system , immunology , concomitant , population , antibody , typing , heterozygote advantage , phenotype , medicine , kidney , biology , genotype , genetics , environmental health , gene
SUMMARY In a population of 282 Caucasoid patients in end‐stage renal failure (ESRF) Gm and Km typing has confirmed a significant increase in the frequency of the Gm 1,2,17;21 haplotype. This was confined to an increase in the number of heterozygous Gm(1, 2, 3, 17; 21, 5, 10, 13, 14) individuals. A concomitant decrease in the frequency of presumptive Gm(3, 5, 10, 13, 14) heterozygotes was also confirmed. Analysis of individual renal diseases revealed significant immunoglobulin allotype, phenotype and haplotype frequency deviations in those patients presenting with hypertension, glomerulonephritis or pyelonephritis. The allotype distribution in patients with physical abnormalities of the urinary‐genital tract, whether congenital or acquired, was normal.