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THE ARRANGEMENT OF H‐2 CLASS I GENES IN MOUSE t HAPLOTYPES
Author(s) -
Rogers John H.,
Lyon Mary F.,
Willison Keith R.
Publication year - 1985
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1985.tb00842.x
Subject(s) - haplotype , genetics , biology , gene , phenotype , chromosome , function (biology) , allele
SUMMARY The t haplotypes of mouse chromosome 17 bear a number of interesting mutations and rearrangements, some of which map close to the H‐2 complex. Since there are many H‐2 class I genes of unknown function, we have investigated their arrangement in t haplotypes using genomic Southern blots. We present a detailed chart of the H‐2 w30 (t w12 ) complex, and compare it with the arrangement in other t haplotypes and standard mouse haplotypes. The chart shows duplications, deletions, and reshuffling of conserved and divergent regions. The two major features of the t arrangement‐large deletions in the Qa and Tla regions–have analogues in some standard strains, so it is unlikely that these deletions are responsible for t ‐specific phenotypes. The differences between t and standard mouse strains are similar, in nature and in degree, to those between different standard strains.