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NON‐SPECIFIC REGULATION OF IMMUNE RESPONSIVENESS TO A THYMUS‐INDEPENDENT ANTIGEN, TNP‐LPS, IN HIGH AND LOW RESPONDER LINES OF MICE
Author(s) -
Sant'Anna O. A.,
Ibañez O. M.,
Gennari M.,
Mevel J. C.,
Siqueira M.,
Mouton D.
Publication year - 1985
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1985.tb00838.x
Subject(s) - immune system , antigen , immunology , biology , microbiology and biotechnology
SUMMARY Responsiveness to a thymus‐independent (TI‐1) antigen, TNP‐LPS, was investigated in the high and low responder lines of mice resulting from four independent selective breedings carried out for antibody production to various complex natural immunogens (selections I, III, IV and V). The superiority of the high responder vs . the low responder line was generally observed, confirming that the genes accumulated through selective breeding can modify the responsiveness to unrelated antigens including TI antigens.Two special features were observed in selection III: (1) A secondary response to TNP‐LPS: higher peak values and IgG isotype antibody production were obtained in the H line. (2) Pretreatment with LPS modified the responses to TNP in the L line only.