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GENETIC DIFFERENCES BETWEEN TWO SUBSTRAINS OF NZB MICE *
Author(s) -
Oikawa T.,
Katoh H.,
Shoji Y.,
Esaki K.,
Ishikawa M.,
Yuhki N.,
Kuzumaki N.,
Tateno M.,
Yoshiki T.
Publication year - 1985
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1985.tb00831.x
Subject(s) - genetics , biology
SUMMARY We have compared the NZB/BINJ (/NJ) and NZB/BlPt (/Pt) mouse substrains with respect to a number of immunological and biochemical polymorphisms. In agreement with earlier findings by other workers, we detected histocompatibility antigen difference(s) between the two substrains. Serological analysis indicated that /NJ and /Pt expressed the same allotypes of H‐2, Thy‐1 and Lyt‐1 antigens, while they differed for the Lyt‐2 antigen. Amongst 15 biochemical polymorphisms, which we assayed, /NJ and /Pt differed for four, namely Pep‐3, Mup‐1, Gpd‐1 and Hbb. In addition, the two NZB substrains differed for the Hc marker (haemolytic complement).