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Ir GENE CONTROL OF T AND B CELL RESPONSES TO DETERMINANTS IN (Glu Lys Ala) TERPOLYMERS
Author(s) -
Babu Uma Mahesh,
Lai ChangHai,
Maurer Paul H.
Publication year - 1984
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1984.tb01061.x
Subject(s) - haplotype , immune system , biology , t cell , microbiology and biotechnology , gene , antibody , cell , antigen , immunology , genetics , allele
SUMMARY All mice responding to the terpolymer GLA 40 make GL, GA and GLA specific antibodies irrespective of their response to GL or GA alone. The mice displayed positive T cell proliferative responses against the homologous terpolymer, but no T cell responses were obtained with GL, which is non‐immunogenic in mice. T cells from GLA immune mice, which are also responders to GA, such as mice of H‐2 haplotypes a, b, d, k and r , could be stimulated by GA. T cells from GLA immune mice of H‐2 haplotypes p and q which are non‐responders to GA could not be stimulated by GA. On the other hand, T cells from H‐2 s mice immune to GLA and which are also responders to GA alone could not be stimulated by GA. Thus mice of H‐2 haplotypes p, q and s recognize the terpolymer via ‘GLA' determinants alone, whereas mice of H‐2 haplotypes a, b, d, k and r may recognize both GA and GLA determinants in GLA terpolymer.