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TWO UNLINKED GENETIC LOCI INTERACT TO CONTROL THE HUMAN IMMUNE RESPONSE TO TYPE III GROUP B STREPTOCOCCAL ANTIGEN
Author(s) -
Pandey J. P.,
Baker Carol J.,
Kasper D. L.,
Fudenberg H. H.
Publication year - 1984
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1984.tb01051.x
Subject(s) - immune system , streptococcus , antigen , polysaccharide , immunization , microbiology and biotechnology , group a , biology , group b , antibody , immunology , bacteria , medicine , genetics , biochemistry
SUMMARY Serum samples were collected from 30 healthy adult Caucasian volunteers before and after immunization with native type III polysaccharide of group B streptococcus. Serum antibody to this polysaccharide was measured and sera were typed for several Gm and Km (1) allotypes. A significant interactive effect of Gm (23) and Km (1) was found on immune responsiveness to native type III group B streptococcus polysaccharide antigen.