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GENETIC LIMITS OF THYMIC IMMUNOSUPPRESSION OF ANTI‐HAPTEN ANTIBODY PRODUCTION IN XENOPUS LAEVIS LAEVIS , THE SOUTH AFRICAN CLAWAD TOAD
Author(s) -
Ruben L. N.,
James Heidi S.,
Clothier R. H.,
Balls M.
Publication year - 1984
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1984.tb01041.x
Subject(s) - xenopus , toad , biology , hapten , immunosuppression , african clawed frog , antigen , amphibian , salientia , antibody , immunology , microbiology and biotechnology , genetics , gene , endocrinology , ecology
SUMMARY Thymic immunosuppression in adult Xenopus laevis laevis , the South African clawed toad, is antigen‐dependent and antigen‐specific, but it is not genetically restricted. In this report, we show that combination in vitro with a thymus from an immunized Xenopus laevis laevis can suppress antibody production to a hapten from spleen fragments, if the spleen fragments are derived from a subspecies of Xenopus laevis or a species of Xenopus which shares the same diploid chromosome number (2N = 36). Some aspects of the evolution of thymic immunosuppression are considered in the light of these results.