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GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN
Author(s) -
Krco C. J.,
Abramson Ellen J.,
Yoshoka N.,
Atassi M. Z.,
David C. S.
Publication year - 1984
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1984.tb01037.x
Subject(s) - biology , clone (java method) , gene , immune system , immunity , antigen , in vitro , genetics , immunology , chain (unit) , microbiology and biotechnology , physics , astronomy
SUMMARY Monoclonal anti‐Ia inhibition experiments were conducted to confirm and extend genetic mapping data of I‐A gene control of immunity to human haemoglobin (Hb). It was found that the A β gene is of critical importance in conferring immunity to the α‐chain and β‐chain subunits of Hb. A possible involvement of I‐E region genes in B10.D2 mice to β‐chain is discussed. Through the use of an α‐chain specific T cell clone data, is obtained indicating that an intact Ia.8 + A β chain is necessary for antigen presentation in vitro .