Premium
INFLUENCE OF NON‐H‐2 GENES ON THE IN VIVO RESPONSE TO PENICILLIN‐TREATED AUTOLOGOUS PLATELETS
Author(s) -
Claas Frans H. J.,
Blankert J. J. Han,
RooduynMoerel Letty,
Rood Jon J. van
Publication year - 1984
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1984.tb00818.x
Subject(s) - penicillin , platelet , in vivo , immunology , biology , antigen , microbiology and biotechnology , antibiotics
SUMMARY Mice of different inbred strains were injected intravenously on day O and 6 with autologous platelets incubated in a penicillin solution. After the second injection mice of most strains died immediately with anaphylactic symptoms. Both passive transfer experiments and indirect immunofluorescence studies suggest that a serum factor (probably IgM) is involved in this phenomenon. Only mice with a C3H background were unable to respond to autologous penicillintreated platelets, although C3H platelets did induce a lethal response in B10.A mice. Experiments in which B10.A mice were primed with autologous penicillin‐treated platelets and rechallenged with allogeneic penicillin‐treated platelets, showed that the response is directed against a polymorphic non‐H‐2 antigen in combination with penicillin.