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POLYMORPHISM OF THE COMPLEMENT COMPONENT C6 IN JAPANESE
Author(s) -
Tokunaga K.,
Yukiyma Y.,
Omoto K.
Publication year - 1983
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1983.tb01029.x
Subject(s) - biology , isoelectric focusing , allele , neuraminidase , genetics , complement (music) , polymorphism (computer science) , inheritance (genetic algorithm) , population , allele frequency , gene , demography , biochemistry , virus , complementation , sociology , phenotype , enzyme
SUMMARY Genetic polymorphism of human C6 was investigated in Japanese using isoelectric focusing and a specific haemolytic overlay method. Three common and six rare allotypes were identified. Five of these nine allotypes were reference‐typed by the International Reference Laboratory. Five of the six rare allotypes were considered to be new. The allele frequencies were estimated in the population study as follows: C6 A 0.427, C6 B 0.483 C6 B2 0.076, and the rere alleles ( A3, A21, M1, M2, B3 , and B4 ) 0.041.Inheritance of the three common and the two rare (A3 and M1) allotypes was demonstrated in the family study. The patterns obtained by the pretreatment with neuraminidase are presented.