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MONOCLONAL ANTI‐B PRODUCED BY THE IMMUNIZATION OF MICE WITH SOLUBLE SALIVARY GLYCOPROTEINS
Author(s) -
Barrie, E. K.,
Fraser, R. H.,
Munro, A. C.,
Williamson,* A. R.,
Hamilton, E. A.,
Mitchell, R.
Publication year - 1983
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1983.tb01015.x
Subject(s) - monoclonal antibody , glycoprotein , immunization , antibody , saliva , immunology , monoclonal , salivary gland , biology , microbiology and biotechnology , chemistry , biochemistry
SUMMARY IgM and IgG mouse monoclonal antibodies with specificity for the blood group B determinant have been produced by immunization of mice with a partially purified salivary glycoprotein. These antibodies have been characterized and one of the IgM antibodies showed potential as a grouping reagent. The ready availability of these salivary blood group substances offers the potential to produce a wide range of related monoclonal antibodies.