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Gm ALLOTYPES IN SWEDISH MYASTHENIA GRAVIS PATIENTS
Author(s) -
Smith C. I. E.,
Grubb R.,
Hammarström,and L.,
Matell G.
Publication year - 1983
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1983.tb01010.x
Subject(s) - myasthenia gravis , thymoma , medicine , antibody , phenotype , immunology , human leukocyte antigen , disease , population , gastroenterology , antigen , biology , genetics , environmental health , gene
SUMMARY Gm phenotype frequencies were examined in 112 Swedish myasthenia gravis patients. The G1m 1,2,3 phenotype frequency in the total patient material did not differ significantly from that found in the normal population. However, when patients were subdivided, three different patient groups were observed with regard to Gml frequency: (1) Thymoma patients having a low frequenc of Gm1, (2) Non‐thymoma patients with a mild disease having a low frequency of Gm1 and (3) Non‐thymoma patients with a severe disease having a high frequency of Gm1. When patients were subdivided according to presence or absence of HLA‐B8 and Gm1 respectively, severe symptoms were less frequent in the HLA‐B8+, Gm(‐1) group as compared to the HLA‐B8+, Gm(+1) group. Furthermore, there was an increased frequency of sera with anti‐immunoglobulins not inhibitable by pooled control immunoglobulins.