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H‐2K RESTRICTION OF THE T CELL‐MEDIATED LYSIS OF A CHEMICALLY‐INDUCED BALB/c FIBROSARCOMA
Author(s) -
Colombo M. P.,
Rodolfo Monica,
Parmiani G.
Publication year - 1983
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1983.tb00812.x
Subject(s) - ctl* , fibrosarcoma , antigen , cytotoxic t cell , immune system , major histocompatibility complex , cytotoxicity , lytic cycle , biology , balb/c , histocompatibility , immunology , microbiology and biotechnology , t lymphocyte , human leukocyte antigen , cd8 , biochemistry , in vitro , virus , genetics
SUMMARY Previous work has shown that a cytotoxic T lymphocyte (CTL) immune response of syngeneic mice immunized with a chemically‐induced BALB/c ( H‐2 d ) fibrosarcoma was directed against an individual tumour‐associated antigen. To see whether this reaction was restricted by products of the major histocompatibility complex (MHC), anti‐H‐2 alloantisera to K or D antigens were used to interfere with the CTL‐mediated immune response. Antisera to K d but not to D d antigens inhibited the lytic activity of CTL against fibrosarcoma cells. In addition, the study of the CTL response in F 1 → P antitumour immunized chimeric mice showed that antitumour cytotoxicity developed only when F 1 and parental host shared the K d region. Both experiments strongly indicate that recognition of the individual tumour‐associated antigen of the BALB/c fibrosarcoma is restricted by the products of H‐2K d genes.