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IgG AND IgA HEAVY CHAIN ALLOTYPES IN TYPE 1 DIABETES
Author(s) -
Bertrams J.,
Schoeps L.,
Baur M. P.,
Luboldt W.,
Loghem E. van
Publication year - 1983
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1983.tb00807.x
Subject(s) - haplotype , biology , locus (genetics) , immunoglobulin heavy chain , phenotype , type 1 diabetes , immunology , immunoglobulin a , genetics , diabetes mellitus , antibody , genotype , gene , immunoglobulin g , endocrinology
SUMMARY IgG and IgA heavy chain allotypes were determined in the sera of 483 Caucasian Type 1 diabetes patients and 503 Caucasian healthy controls. There was no significant difference between patients and controls neither on the level of Gm phenotype frequencies nor on the level of Gm three‐locus and two‐locus haplotype frequencies. A selective IgA deficiency was found in 14 patients (2.9%) but in none of the control individuals (P<10 ‐4 ).