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GENETIC LINKAGE OF SUBGROUP C ROUS SARCOMA VIRUS‐INDUCED TUMOR EXPRESSION IN CHICKENS TO THE IR‐GAT LOCUS OF THE B COMPLEX
Author(s) -
Gebriel G. M.,
Nordskog A. W.
Publication year - 1983
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1983.tb00799.x
Subject(s) - biology , rous sarcoma virus , genotype , group b , locus (genetics) , virology , immune system , virus , group a , genetics , gene , medicine
SUMMARY Two B complex genotypes, B 1 B 1 and B 19 B 19 , of outbred line S1, were tested for low and high immune response to GAT, from which four recombinants were recovered: B 1 B 1 GAT‐hi and lo , and B 19 B 19 GAT‐hi and ‐lo . Also included in the study were birds of B 2 B 2 genotype with an intermediate level of immune response to GAT.A total of 225 birds of these groups were challenged with the Bryan strain of Rous Sarcoma virus subgroup C, RSV (RAV‐7), by inoculation into the wing web at five weeks of age. The B 1 B 1 genotype had the lowest percentage of regressors (17.6%), B 19 B 19 had the highest (42.2%), and the B 2 B 2 genotype was intermediate (23.7%). Combining the results of GAT response over the B 1 B 1 and B 19 B 19 genotypes, 14.0% of GAT‐lo and 37.8% of GAT‐hi regressed their tumours, respectively. The highly significant (P ≤ 0.01) difference between the combined GAT‐hi and ‐lo groups would suggest that the Rs locus controlling tumour regression induced by the subgroup C virus is closely linked to the region controlling immune response to GAT, but the data also provides evidence that the B‐F region of the B complex also plays an important role in RSV‐induced tumour regression.