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ROUS SARCOMA VIRUS‐INDUCED TUMOURS IN MICE: II. CONTRIBUTION OF H‐2 AND NON‐H‐2 ALLOANTIGEN BARRIERS TO TUMOUR IMMUNOGENICITY IN VIVO
Author(s) -
Forni G.,
Giovarelli M.,
Sarzotti M.,
Whitmore A. C.
Publication year - 1983
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1983.tb00797.x
Subject(s) - rous sarcoma virus , biology , immunogenicity , fibrosarcoma , antigen , histocompatibility , immune system , in vivo , virology , virus , immune reaction , allele , immunology , gene , genetics , human leukocyte antigen
SUMMARY The features of the immune recognition of a murine fibrosarcoma induced by Rous sarcoma virus were tested in histocompatible and histoincompatible mice. No evidence of a genetic regulation of spontaneous reactivity to tumour‐associated antigens was found in various histocompatible F 1 hybrids. Incompatibility in multiple minor histocompatibility antigens triggers a host reaction incapable of causing tumour rejection in some cases. The growth rate of incipient tumours is unaffected, whereas that of already visible tumoour masses is significantly delayed. Admixture to the challenge of inactivated leukocytes bearing the same minor histocompatibility antigens as the tumour triggers a significantly stronger reaction. The reaction of hosts incompatible in the H‐2K or H‐2DL regions is quite efficient. However, the intensity of the immune reaction to H‐2DL s antigens displayed by tumour cells is markedly dependent on the alleles of genes located in the central regions of the H‐2 complex.