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HLA A*, B*‐BF* AND C4 A* , ALLELE ASSOCIATIONS, WITH SPECIAL REFERENCE TO BF*S07 , IN THE TUNISIAN POPULATION
Author(s) -
Helal A. N.,
Lefrance G.,
Hauptmann G.,
Goetz Joëlle,
Tongio MarieMarthe,
Davrinche C.,
Rivat C.,
Cavelier Brigitte,
Chibani J.,
Chaabani H.
Publication year - 1983
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1983.tb00796.x
Subject(s) - linkage disequilibrium , haplotype , allele , biology , genetics , locus (genetics) , human leukocyte antigen , hla a , hla b , population , allele frequency , gene , antigen , medicine , environmental health
SUMMARY The HLA A*2, Bw*50‐BF*S07‐C4 A*2, B*l linkage group was transmitted unambiguously in four unrelated Tunisian families. In one of these, another allele association, also carrying BF*S07, HLA A*9, Bw*50‐BF* S07‐C4 A*1, B*1 , was encountered. The previously reported linkage disequilibrium between BF*S07 and HLA Bw*50 , a subtypic speficity of HLA Bw*21 , is confirmed in our study. The C4 A*2, B*1 , haplotype, rare in the other populations until now studied, seems more frequent in Tunisia since it has been also found linked to HLA A* 11, B*27 and BF*S in one of these familie. Other allele associations were unambiguously demonstrated with predominantly the C4 A*3, B*1 haplotype, particularly a rare HLA A*3, B*18‐BF* F1‐C4 A*3, B*1 linkage group. A silent gene at the C4 A locus was found linked to HLA B* .