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GENETIC CONTROL OF CELL‐MEDIATED IMMUNITY IN THE RAT:II. SHARING OF EITHER THE RTI. A OR RTI. B LOCUS IS SUFFICIENT FOR TRANSFER OF ANTIMICROBIAL RESISTANCE
Author(s) -
Jungi T. W.,
Kunz H. W.,
Gill T. J.,
Jungi Ruth
Publication year - 1982
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1982.tb01005.x
Subject(s) - locus (genetics) , listeria monocytogenes , biology , listeria , antigen , major histocompatibility complex , microbiology and biotechnology , adoptive cell transfer , immune system , immunity , t cell , immunology , genetics , bacteria , gene
SUMMARY The MHC restriction criteria for T cells activating macrophages in vivo and mediating antimicrobiol resistance to Listeria monocytogenes were determined. Antimicribiol resistance could be transferred by T cell in order of decreasing efficiency from syngeneic. RT1A. compatible, RTI.B compatible and RT1 incompatible donors. Alloreactive T cells responding to either A locus or B locus encoded antigens in a graft‐versus‐host reaction were also able to activate macrophages. Approximately five times as many MLC‐reactive precursors responded to B locus alloantigens as to A locus alloantigens, but A ‐resticted Listeria ‐specific T cells wre considerably more numerous (or more efficient) in Listeria infected hosts than were B ‐restricted, Listeria ‐specific T cells. This was unexpected, since A ‐restricted, Listeria ‐specific T cells failed to transfer delayed hypersensitivity (DTH) to soluble bacterial antigens.