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RATS HIGHLY SUSCEPTIBLE TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS OBTAINED BY CROSSING RATS FROM STRAINS WITH LOW SUSCEPTIBILITY
Author(s) -
Källén Bengt
Publication year - 1982
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1982.tb00991.x
Subject(s) - biology , experimental autoimmune encephalomyelitis , gene , strain (injury) , genetics , chromosome , encephalomyelitis , immunology , multiple sclerosis , immune system , anatomy
SUMMARY By crossing and back‐crossing three strains of rats, Brown‐Norway, Fischer, and PVG, none of which is definitely susceptible to experimental autoimmune encephalomyelitis (EAE), it is possible to obtain fully susceptible animals. Genetic analysis indicates the presence of Ir ‐genes in at least two of the strains (Fisher and PVG) related to the AgB complex, and genes of ‘resistance’ located on another chromosome. The latter appear to be different in the three strains; also the BN strain, which perhaps does not carry an Ir‐EAE gene, apparently carries effective genes of resistance.