Premium
SURFACE MARKERS OF PRIMATE B AND T LYMPHOID CELL LINES IDENTIFIED BY ANTIBODIES TO HUMAN AND SIMIAN LYMPHOCYTE ANTIGENS
Author(s) -
Neubauer R. H.,
Marchalonis J. J.,
Strnad B. C.,
Rabin H.
Publication year - 1982
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1982.tb00976.x
Subject(s) - biology , antigen , marmoset , antibody , t lymphocyte , monoclonal antibody , surface immunoglobulin , lymphocyte , microbiology and biotechnology , b cell , t cell , immunology , virology , immune system , paleontology
SUMMARY Simian B and T lymphoid cell lines were shown to maintain surface markers found on mature lymphocytes in vivo . The T lymphoid cell lines expressed Ia‐like antigens on their surfaces, further suggesting that they represent mature, activated T cells. These Ia antigens show a structural similarity to Ia on human cells although some diversity exists. The Ia antigen expressed on T lymphoid cell lines was shown to be very similar to those on B lymphoid cell lines. Owl monkey and marmoset T lymphoid cell lines were also shown to express a V H immunoglobulin‐related determinant, a marker which is thought to be associated with T cell antigen receptor. Owl monkey and marmoset T cell lines express a surface antigen which identifies the sheep erythrocyte receptor on human T cells and some of these lines express an antigen found on human helper T cells. It is noteworthy that substantial conservation of surface components has occurred within primate evolution such that monoclonal antibodies to human Ia, OKT‐11a and Leu 3a markers can be used to type lymphocytes of lower primates.