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GENETIC ANALYSIS OF H‐2 LINKED GENE(S) AFFECTING EARLY MOUSE EMBRYO DEVELOPMENT
Author(s) -
Goldbard S. B.,
Verbanac Kathryn M.,
Warner Carol M.
Publication year - 1982
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1982.tb00966.x
Subject(s) - biology , embryo , haplotype , congenic , genetics , embryogenesis , gene , genotype
SUMMARY The number of cells in preimplantation mouse embryos of different H‐2 haplotypes was analysed. It was found that embryos of the H‐2 k haplotype have fewer cells per embryo than those of the H‐2 b haplotype. By analysing reciprocal congenic pairs of mice it was demonstrated unequivocally that slow development is linked to the H‐2 k haplotype and fast development to the H‐2 b haplotype. The gene(s) in the H‐2 complex which influence early mouse embryo development have been named Ped : preimplantation embryo development. Analysis of F 1 hybrid embryos showed that fast development is dominant. Reciprocal F 1 crosses yielded identical results, which indicated there was no apparent effect of the maternal egg cytoplasm on Ped gene expression. Analysis of F 2 and back‐cross embryos was consistent with the interpretation that there is a major gene located in the H‐2 complex ( Ped ), which is modified by environment and genetic background, that influences early mouse embryo development.