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INHIBITION OF SECONDARY IgG RESPONSES BY MONOSACCHARIDES: EVIDENCE FOR I‐REGION CONTROL
Author(s) -
Tomaska Luba D.,
Parish Ch. R.
Publication year - 1982
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1982.tb00964.x
Subject(s) - monosaccharide , in vitro , major histocompatibility complex , carbohydrate , biology , inhibitory postsynaptic potential , biochemistry , chemistry , gene , immunology , endocrinology
SUMMARY Certain monosaccharides selectively inhibit secondary IgG responses in vitro . Genetic analyses described in this report revealed that the inhibitory sugars differed between mouse strains and these differences mapped to the I‐J and I‐C subregions of the murine MHC. These results imply that interaction between T and B lymphocytes can involve the recognition of I ‐region controlled carbohydrate structures.