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COMPARISON OF THE SEGREGATION OF SHEEP HISTOCOMPATIBILITY GENES OLA‐A1, A8, B7, B9 AND OLX‐5 IN EIGHTEEN HAMSTER X SHEEP FIBROBLAST HYBRID LINES
Author(s) -
MILLOT P.
Publication year - 1982
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1982.tb00790.x
Subject(s) - biology , hamster , hybrid , haplotype , genetics , major histocompatibility complex , locus (genetics) , gene , histocompatibility , fibroblast , allele , microbiology and biotechnology , cell culture , antigen , human leukocyte antigen , botany
Summary Four OLA factors of the ovine histocompatibility complex and the OLX‐5 factor were recognized in hamster cell x sheep fibroblast hybrids, by means of absorption of OLA reagents with hybrid cells. Segregation of these factors could be studied in eighteen independent hybrids. In the case described, the four OLA factors were distributed into two haplotypes isolated in some hybrids. The heterozygous OLX‐5 factor was linked to only one haplotype; nevertheless a dissociation, occurred in one hybrid (relative to five simultaneous transmissions), is in agreement with a previous genetic study showing a loose linkage between the OLA complex and the OLX locus.