Premium
IMMUNOGLOBULIN ALLOTYPES AND IMMUNE RESPONSE TO MENINGOCOCCAL POLYSACCHARIDES A AND C
Author(s) -
Pandey J. P.,
Ambrosch F.,
Fudenberg H. H.,
Stanek G.,
Wiedermann G.
Publication year - 1982
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1982.tb00779.x
Subject(s) - allotype , biology , immune system , antibody , immunology , phenotype , group a , immunoglobulin g , group b , gene , genetics , medicine
Summary Serum samples were collected from 113 healthy Caucasian volunteers before and after vaccination with meningococcal polysaccharides (MPS) group A and group C. Antibodies to MPS group A and group C were measured and sera were typed for several Gm and Km (1) allotypes. A significant association was found between the Gm 1,3,17; 5,13,14,21 phenotype and low immune responsiveness to MPS group A. These results suggest the possible existence of an immunoglobulin allotype‐linked immune suppression ( Is ) gene( s ) in man.