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UNUSUAL HEAVY CHAINS OF HUMAN IgG IMMUNOGLOBULINS: REARRANGEMENTS OF THE CH DOMAIN EXONS
Author(s) -
Lefranc G.,
Lefranc Marie Paule,
Helal A. N.,
Boukef K.,
Chaabani H.,
Gandoura M. Sfar,
Loghem Erna van
Publication year - 1982
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1982.tb00777.x
Subject(s) - exon , biology , intron , genetics , immunoglobulin heavy chain , antibody , coding region , immunoglobulin light chain , dna , gene
Summary Unusual combinations—unexpected sets, excess or lack—of antigenic determinants, or Gm allotypes, on the constant regions of the heavy chains of the human IgG1 and IgG3 immunoglobulins are accounted for in terms of genetic events (exchanges, duplications and deletions) involving the DNA sequences, or exons, coding for the three CH1‐, CH2‐ and CH3 domains of the γ1 and γ3 chains. Equal and unequal cross‐overs at the level of the introns without damage to the CH exons are postulated.