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MURINE IMMUNE MEMORY TO A TI‐2 ANTIGEN, DNP‐FICOLL: CARRIER‐SPECIFICITY, GENETIC ENHANCEMENT AND PHENOTYPIC DOMINANT INHERITANCE
Author(s) -
Schott C. F.,
Lizzio Elaine F.,
Merchant B.
Publication year - 1981
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1981.tb00953.x
Subject(s) - ficoll , antigen , immune system , biology , phenotype , immunology , inheritance (genetic algorithm) , immunological memory , genetics , microbiology and biotechnology , gene , immunity , in vitro , peripheral blood mononuclear cell
SUMMARY C3H/HeN x NZB/BIN F 1 mice were primed and challenged with DNP‐Ficoll, a thymic independent (TI‐2) antigen. They developed strong IgM and IgG carrier‐specific memory responses: DNP‐pneumococcal polysaccharide or DNP‐haemocyanin challenge did not elicit memory responses. The IgG response component appeared to be inherited dominantly from the C3H/HeN parent. The IgM component resulted from genetic enhancement.