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GENETIC CONTROL OF THE IMMUNE RESPONSE TO MYOGLOBIN: VIII. CONTROL OF ANTIBODY AFFINITY
Author(s) -
Young C. R.,
O'Connor G. P.,
Atassi M. Z.
Publication year - 1981
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1981.tb00943.x
Subject(s) - myoglobin , biology , antibody , antiserum , microbiology and biotechnology , immunology , biochemistry
SUMMARY We have previously shown that the antibody response to mammalian myoglobins is under genetic control. In the present study we examined antibodies to sperm‐whale, Atlantic bottlenosed dolphin, Black Sea dolphin, horse and badger myoglobins, raised in high responder strains of mice, to ascertain whether there is genetic control of antibody affinity to mammalian myoglobins. Using antisera of varying dilutions, the binding to 125 I‐labelled homologous myoglobins was studied by inhibition with homologous myoglobin over a wide range of inhibitor concentration in a modified Farr assay. The results indicated that there are no large differences between high responder strains of mice in the affinity of antibodies to mammalian myoglobins.