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Pi‐Gm LINKAGE: EVIDENCE FOR LINKAGE IN MALES BUT NOT IN FEMALES AND FOR AN EFFECT OF THE S ALLELE OF THE Pi SYSTEM
Author(s) -
ChapuisCellier C.,
Verdier M.,
Lepetit J. C.,
Fudenberg H. H.,
Arnaud P.
Publication year - 1981
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1981.tb00767.x
Subject(s) - linkage (software) , genetic linkage , biology , allele , genetics , gene
Summary Linkage between the Pi (alpha 1 ‐antitrypsin) and Gm (immunoglobulin heavy chain) loci was studied in thirty‐four families including forty‐one informative parents and 142 children. In females, the results did not provide evidence for linkage (posterior probability of non ‐linkage 0.98). In contrast, in males, there was strong evidence for linkage (peak lod 3.9 at 0 = 0.18, posterior probability of linkage 0.98). The two populations appeared to be significantly different (0.001 < P < 0.01) with respect to the heterogeneity criterion of Morton. In addition, the effect of the possession of the S allele (associated with significantly decreased serum alpha 1 ‐antitrypsin levels) was studied in fifteen informative parents and fifty‐three children of the same group. No evidence for or against linkage was found in females, but in males close linkage between Pi S and Gm was demonstrated (peak lod 7.7 at 0 = 0.05, posterior probability of linkage 0.9999). These data indicate significant linkage between Pi and Gm in males but not females and close linkage between the Pi S and Gm markers in males.