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GENETIC ANALYSIS OF SUSCEPTIBILITY TO EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN GUINEA‐PIGS
Author(s) -
Teitelbaum Dvora,
Ar Ruth
Publication year - 1981
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1981.tb00748.x
Subject(s) - major histocompatibility complex , encephalomyelitis , guinea pig , biology , gene , immunology , strain (injury) , genetics , histocompatibility , genetic predisposition , antigen , multiple sclerosis , human leukocyte antigen , anatomy
Summary Genetic analysis of susceptibility to experimental allergic encephalomyelitis (EAE) was performed in guinea‐pigs. The results indicate the existence of two Ir genes to EAE in susceptible strain 13 guinea‐pigs. One gene is linked to the major histocompatibility complex (MHC) of this species, while the other one is located outside the MHC. The two genes segregate independently and both of them must be expressed to render the animal susceptible to EAE.