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ALLOGENEIC RESTRICTION IN THE RAT: GENETIC BASIS OF RESTRICTION OF THE T CELL MEDIATORS OF DELAYED‐TYPE HYPERSENSITIVITY AND ANTIMICROBIAL RESISTANCE TO LISTERIA MONOCYTOGENES *
Author(s) -
Jungi T. W.,
McGregor D. D.
Publication year - 1980
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1980.tb00934.x
Subject(s) - biology , major histocompatibility complex , listeria monocytogenes , microbiology and biotechnology , antigen , delayed hypersensitivity , antimicrobial , gene , phenotype , histocompatibility , immunology , genetics , bacteria , human leukocyte antigen
Summary The genetic basis of the restriction imposed on T cell mediating acquired antimicrobial resistance and delayed‐type hypersensitivity (DTH) to Listeria in the rat was investigated. Sharing of MHC ‐coded genes between donors of sensitized T cells and antigen‐stimulated recipients was both necessary and sufficient for efficient transfer of both resistance and DTH. Evidence to support this assumption was derived from experiments involving allogeneic transfers within major histocompatibility complex (MHC)‐compatible strains and across MHC‐barriers. Further support came from linkage studies with backcrossed rats and with the progeny of F 1 rats mated with an unrelated strain. An unexpected difference in the compatibility requirements for effective transfer of DTH and resistance was noted in experiments involving the BI strain (formerly called B3). Thus, while B‐region compatibility was obligatory for expression of DTH in recipients of sensitized T cells, considerable levels of protection could be transferred to either A‐region or B‐region compatible hosts.