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THE GUINEA‐PIG I‐REGION: III. DISTRIBUTION OF Ia ANTIGENS IN INBRED AND PARTIALLY INBRED STRAINS
Author(s) -
Shevach E. M.,
Geczy A. F.,
Weck A. de,
Schwartz B. D.
Publication year - 1980
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1980.tb00933.x
Subject(s) - inbred strain , biology , strain (injury) , immunogenetics , serology , histocompatibility , genetics , guinea pig , antigen , antibody , gene , human leukocyte antigen , anatomy
Summary We have used a combined serologic and structural approach to study the distribution of I‐region associated (Ia) antigens in nine strains of inbred and partially inbred guinea‐pigs. All of the inbred strains studied with the exception of strain 2 animals were found to share one or more I‐subregions with inbred strain 13 animals. The BIOAD, R9, OM3, and BIOAC strains have the same I‐region as strain 13 animals; the B/Lac strain has two subregions in common with strain 13, while the BIOB strain has a single subregion in common with strain 13. The availability of a number of different guinea‐pig strains with well characterized major histocompatibility complexes should facilitate the continuing use of this species in studies of immunogenetics, transplantation, and tumour immunology.