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DISCONTINUOUS GENES AND DNA SEQUENCE TRANSPOSITION: A MODEL FOR IMMUNOGLOBULIN CHAIN SYNTHESIS
Author(s) -
Lefranc G.,
Lefranc MariePaule
Publication year - 1980
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1980.tb00930.x
Subject(s) - genetics , biology , gene , transposition (logic) , dna , homology (biology) , immunoglobulin heavy chain , coding region , mathematics , geometry
Summary An attempt is made to account for immunoglobulin chain synthesis in terms of genetic events involving IS or controlling elements analogous to those found in bacteria, maize and drosophila. Transposition of variable and constant genes and normal immunoglobulin chain synthesis as well as qualitative and quantitative abnormalities might be explained by such regulatory elements. Intrachromosomal transpositions over short distances would be expressed as apparent hypermutability or redundancy of the variable DNA segment. The constant gene might comprise four sequences coding for the three homology domains and the hinge, separated by intervening sequences. A strong preference for shortrange transposition on the same chromosome and immobilization of the controlling element in the end might account for allelic exclusion.