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HIGH FREQUENCY OF THE PROPERDIN FACTOR Bf F1 AND ITS LINKAGE TO HLA IN FRENCH BASQUES
Author(s) -
Ohayon E.,
Mouzon A. de,
Hauptmann G.,
Klein J.,
Abbal M.,
Constans J.,
Mayer S.,
Ducos J.
Publication year - 1980
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1980.tb00739.x
Subject(s) - haplotype , linkage (software) , linkage disequilibrium , biology , genetics , allele frequency , allele , human leukocyte antigen , population , gene , demography , antigen , sociology
Summary We studied 201 unrelated French Basque individuals for HLA and Bf polymorphisms. The haplotypes of eighty‐seven of them were deduced from family studies. The results show the frequency of the Bf F1 allele (0.1393) which is the highest one currently reported. They confirm the high frequencies of HLA‐Aw19.2 and B18 previously reported in that population and show that a whole haplotype with strong linkage disequilibria, namely Aw19.2, Cw5, B18, Bf F1, DRw3 is frequent. On the other hand, the gene frequency of Bf S is decreased (0.5497) as compared with the other European Caucasoïd populations, while a slight increase in the Bf F gene frequency (0.2960) appears. These results point out that it is of importance to consider the genetic background in choosing the population where linkage disequilibria are to be studied.