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A NEW P k PHENOTYPE IN THE P BLOOD GROUP SYSTEM
Author(s) -
Kundu S. K.,
Evans A.,
Rizvi J.,
Glidden H.,
Marcus D. M.
Publication year - 1980
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1980.tb00738.x
Subject(s) - globotriaosylceramide , glycolipid , chemistry , phenotype , antigen , antibody , blood group antigens , biochemistry , inositol , microbiology and biotechnology , immunology , biology , medicine , receptor , fabry disease , disease , gene
Summary A healthy 22‐year‐old woman was noted to have erythrocytes of the P k phenotype: a strong P k antigen, no detectable P antigen and anti‐P antibody in her serum. Her erythrocytes contained four to six times as much P k glycolipid (globotriaosylceramide or CTH) and approximately half as much P glycolipid (globotertraosylceramide or globoside) as normal red cells. The structures of CTH and globoside were characterized by analysis of permethylated sugars and complement fixation in addition to chromaographic mobility and sugar composition. Inasmuch as the erythrocytes of two P k individuals that were analysed previously (Marcus et al ., 1976) contained no detectable globoside, these abnormalities appear o represent a new phenotype in the P blood group system.