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COELIAC DISEASE AND HLA: A FAMILY STUDY
Author(s) -
Robinson B. N.,
Roberts D. F.,
Mather B. A.,
Nelson R.,
Rowlatt A. S.
Publication year - 1980
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1980.tb00732.x
Subject(s) - coeliac disease , human leukocyte antigen , haplotype , allele , etiology , family history , disease , family studies , genetics , immunology , allele frequency , medicine , gene , biology , antigen
Summary In a family study of coeliac disease, HLA types in fifty‐three patients and their relatives were examined. There are no differences in HLA frequencies between child and adult patients. Comparison with a random series of normal controls shows increases frequencies in patients of HLA‐A1 and B8, while the family material shows that there is also an excess of haplotype I‐8 . The excess of homozygotes is thought not to be a factor in the aetiology. Intrafamilial analysis shows that only B8 is significantly associated with the disorder. It is argued that the HLA association does not indicate a ‘coeliac gene’ but that the B8 allele is a major gene in a polygenic system affecting the disorder.