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GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY‐CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB‐CLASSES
Author(s) -
Loghem Erna van,
Sukernik R. I.,
Osipova L. P.,
Zegers B. J. M.,
Matsumoto H.,
Lange and Gerda de,
Lefrance G.
Publication year - 1980
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1980.tb00722.x
Subject(s) - biology , gene duplication , gene , genetics , gene cluster , cluster (spacecraft) , computational biology , computer science , programming language
Summary Individuals with selective absence of IgG1 and IgG2 were discovered by testing for allotypes and isotypes of the respective sub‐classes. These individuals were homozygous for sub‐class deleted Gm‐Am haplotypes, as shown by allotype studies in two families ( Gm‐;…;g;A2ml/Gm‐;n;b;A2ml and Gm‐;n;b;A2ml/Gm‐;…;b;A2ml ) and by a population study of New Guineans ( Gm fa;‐;b;A2m2 ). The individuals with IgGl sub‐class deficiency showed elevation of IgG2, IgG4 and in particular of IgG3. Gene deletion can result from unequal crossing over which renders a complementary chromosome with a duplication of a sub‐class gene. In one family, duplication of γ3 genes was observed to have happened in one of a twin pair. Quantitation of sub‐classes in families with γ1‐ and with γ3‐duplicated haplotypes did not show increased levels of the gene involved.