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A STRAIN SURVEY OF AGE‐DEPENDENT CHANGES IN ANTIGEN ELIMINATION, ANTIBODY FORMATION AND TOLERANCE
Author(s) -
Nakano K.,
Cinader B.
Publication year - 1980
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1980.tb00720.x
Subject(s) - strain (injury) , antigen , antibody , immune system , biology , c57bl/6 , immune tolerance , immunology , microbiology and biotechnology , anatomy
Summary A strain survey has been undertaken to examine polymorphism of age‐dependent changes in antigen elimination, immune responsiveness and tolerance inducibility. In young mice of tested strains, other than C57BL/6J, aggregate‐freed mouse Ig was eliminated faster than was the xenogeneic Ig (RGG); C57BL/6J was the only exception. The rate of elimination increased with age in all strains, tested. Antibody formation to RGG decreased in 3 (BALB/cJ, 129/J, DBA/2J) out of the eleven strains tested at 5‐7 and 31‐40 weeks of age; there was a considerable strain variation in the extent of this decrease. Age‐dependent resistance to tolerance induction was observed in a fraction of animals of H‐2 haplotypes, H‐2 k and H‐2 d .