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HUMAN AND MURINE TUMOURS: CHANGES IN CELL SURFACE STRUCTURES CODED BY THE MAJOR HISTOCOMPATIBILITY COMPLEX REGION
Author(s) -
Ferrone S.,
Pellegrino M. A.,
Callahan G. N.
Publication year - 1980
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1980.tb00709.x
Subject(s) - antigen , serology , receptor , biology , major histocompatibility complex , human leukocyte antigen , immunology , histocompatibility , immune system , cell , epitope , antibody , genetics
Summary Serological and structural changes of surface markers involved in immune reactions may occur in human and murine tumour systems. Thus nine out of twenty‐one human tumour cell lines and SV 40 ‐transformed fibroblasts differed from autologous lymphoblastoid cells or fibroblasts in their reactivity with HLA allonatisera. H‐2 antigens isolated from the murine tumour cells 6C3HED and TP 1422, undergo structural changes. An alien HLA‐B7 was detected in sera from two melanoma patients. The serologic activity on H‐2 antigens was significantly increased in the serum and ascites fluid of tumour bearing mice. Additionally, human SV 40 ‐transformed fibroblatsts acquire receptors for monkey red blood cells and the murine lymphosarcoma cells 6C3HED express receptors for sheep red blood cells.