Premium
GENETIC CONTROL OF THE IMMUNE RESPONSE TO HEN'S EGG‐WHITE LYSOZYME IN MICE: I. ANTIBODY AND T‐LYMPHOCYTE PROLIFERATIVE RESPONSES TO THE NATIVE PROTEIN *
Author(s) -
Okuda K.,
Sakata S.,
Atassi M. Zouhair,
David C. S.
Publication year - 1979
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1979.tb00699.x
Subject(s) - lysozyme , immune system , biology , antibody , antigen , lymphocyte , white (mutation) , t lymphocyte , haplotype , egg white , antibody response , immunology , genetics , gene , allele , biochemistry
Summary We have initiated studies to determine whether the antibody and T‐lymphocyte proliferative responses to lysozyme and its antigenic sites is genetically controlled in mice. Mice of the H‐2 f , H‐2 k and H‐2 p were high responders, while haplotypes H‐2 b , H‐2 d , H‐2 r and H‐2 s were low responders. Studies with recombinants indicated that the immune response is controlled by two H‐2I region loci, one being in the I‐A subregion and the other may be in the I‐C subregions.