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PHYLOGENY OF THE RABBIT γ‐CHAIN DETERMINANTS: A d12‐LIKE ANTIGENIC DETERMINANT IN PRONOLAGUS RUPESTRIS
Author(s) -
HamersCasterman C.,
Wittouck E.,
Van Der Loo W.,
Hamers R.
Publication year - 1979
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1979.tb00692.x
Subject(s) - biology , phylogenetics , immunodiffusion , typing , hemagglutination , haemagglutination inhibition , rabbit (cipher) , ouchterlony double immunodiffusion , locus (genetics) , microbiology and biotechnology , genetics , antigen , gene , antibody , serology , antiserum , statistics , mathematics
Summary A survey for constant region γ‐chain allotypes (de locus) was undertaken in different lagomorph genera. As yet only Pronolagus rupestris , a paleolaginae, showed the presence of a determinant similar to rabbit d12 although it lacked the widespread e15 determinant. All seven individuals possessed the d12 like determinant which was studied by immunodiffusion, haemagglutination inhibition, radiobinding and binding inhibition assays. In addition, a new enzymic method for typing for d12, based on the presence of the asymmetric rabbit hing carbohydrate linked to the d12 characteristic threonine, is presented. This method suggests, however, that, unlike the d12 rabbit, Pronolagus does not seem to have a majority of IgG molecules with a glycosylated hinge.