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ROLE OF THE H‐2 COMPLEX IN THE HOMING AFFINITY OF INJECTED LYMPHOID CELLS TO THE HOST'S LYMPH NODES
Author(s) -
Viklický V.,
Micková Milada
Publication year - 1979
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1979.tb00681.x
Subject(s) - homing (biology) , lymph , lymph node , lymphatic system , immune system , cell , gene , biology , chemistry , immunology , microbiology and biotechnology , pathology , genetics , medicine , ecology
Summary The role of H‐2 and non‐H‐2 gene products was studied in a model of non‐immune cell‐cell interactions which underlie the homing affinity to lymph nodes of injected 51 Cr‐labelled lymph node cells. The effect of various donor‐recipient combinations was tested by comparing the allogeneic/syngeneic ratio of radioactivity recovered from the lymph nodes. The homing affinity was reduced to about 50% when the donor‐recipient incompatibility extended over the whole H‐2 chromosome. When confined to a single region (H‐2K, I or D) H‐2 incompatibility caused no significant allogeneic inhibition of the homing affinity. The cumulative effect of two partial incompatibilities (K + I or D + I) was, however, reflected in a significant allogeneic inhibition. Non‐H‐2 incompatibilities had, as a rule, a weak effect; the non‐H‐2 gene products may not be directly involved in the cell interactions under test.