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GENETIC CONTROL OF THE IMMUNE RESPONSE TO MAMMALIAN CHYMOTRYPSINS IN MICE
Author(s) -
Young C. R.
Publication year - 1979
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1979.tb00675.x
Subject(s) - immune system , biology , genetics
SUMMARY The primary and secondary immune response to the antigen bovine pancreatic α‐chymotrypsin was investigated in in inbred mice. It was found that strain differences in the immune response only became apparent after secondary immunization. The genetic control of the immune response was investigated in twelve different strains of mice, F 1 , F 2 and F 1 backcross hybrids, following secondary immunization. A continous distribution for the mean antibody responsiveness was obtained. High responsiveness was associated with both the H‐2 haplotype and three non‐H‐2 loci. Furthermore the F 1 hybrids produced a greater quantitative antibody response to chymotrypsin than either of the corresponding parental strains.