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H‐2 LINKED IMMUNE RESPONSE TO MURINE EXPERIMENTAL SCHISTOSOMA MANSONI INFECTIONS
Author(s) -
Claas F. H. J.,
Deelder A. M.
Publication year - 1979
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1979.tb00342.x
Subject(s) - schistosoma mansoni , antigen , eosinophilia , immune system , spleen , biology , congenic , titer , immunology , antibody , antibody titer , schistosomiasis , helminths , biochemistry , gene
Summary Mice of two congenic inbred strains C3H/Sn (H‐2 k ) and C3H. B10 (H‐2 b were infected with 100 Schistosoma mansoni cercariae. After the infection, the following parameters for the immunologica response were studied: worm burden, mortality, antibody titre, spleen index, eosinophilia, delayed type of hypersensitivity and in vitro response to three S. Mansoni antigen preparations. No difference in the worm burden and in the in vitro response to the antigen preparations of adult worm antigen, soluble egg antigens and the egg antilgen MSA 1 , was found. The C3H.B10 mice showed a singificantly higher mortality, antibody titre and delayed type of hyprsensitivity while the C3H/Sn mice showed a significantly higher spleen index and eosinophilia. This indicates that the H‐2 region influences the course of an acute S. mansoni infection, whereas the susceptibility to the infection seems not to be influenced, as is shown by the worm burden