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GENETIC CONTROL OF ANTI‐DNP RESPONSE TO DNP‐BSA GIVEN BY CONTINUOUS INFUSION TECHNIQUE
Author(s) -
Ikeda H.,
Takizawa K.,
Yamamoto T.,
Odaka T.
Publication year - 1979
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1979.tb00337.x
Subject(s) - biology , control (management) , computer science , artificial intelligence
Summary Ten inbred strains of mice were administrated with dinitrophenyl‐bovine serum albumin (DNP‐BSA) at a dose of 30 or 300 μg/day by continuous infusion technique. Anti‐DNP plaque‐forming cells (PFC) in their spleens were assayed 10 to 12 days after the beginning of the infusion. NZB, BALB/c, C3H/He and NC strains were high responders to both doses of DNP‐BSA. KK, SII and TES strains were low responders: the antibody response was low to the dose of 30 μg/day, and high to the dose of 300 μg/day. Breeding tests between high responder BALB/c and intermediate responder DDD mice indicated that the immune response was largely controlled by a gene linked to the H‐2 complex. Similar studies with high responder NZB and low responder TES mice suggested an involvement of a few genes: at least one of the controlling genes may be linked to the H‐2 complex.