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COMPARISON OF THE HAPLOTYPES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE RAT IV. THE SIX ORIGINAL AG‐B HAPLOTYPES
Author(s) -
ŝTark O.,
Kunz H. W.,
Gill T. J.
Publication year - 1979
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1979.tb00336.x
Subject(s) - congenic , haplotype , antiserum , biology , inbred strain , histocompatibility , serology , genetics , ficoll , hemagglutination , major histocompatibility complex , antigen , microbiology and biotechnology , immunology , virology , allele , antibody , gene , human leukocyte antigen , in vitro , peripheral blood mononuclear cell
Summary The six original haplotypes described in the Ag‐B system were compared with their counterparts in the H‐1 system. Antisera to the Ag‐B haplotypes raised in inbred rats and antisera to H‐1 haplotypes raised in congenic lines were tested against various panels of cell from inbred and congenic lines by the dextran and Ficoll haemagglutination methods. The private and strong public specificities detected in both systems were the same, but there were some minor differences in the intermediate and weak reactivities detected. The cross‐reactivity of the antisera raised in inbred rats was broader than that of antisera raised in congenic lines. The identity of the antigenic products detected in the two systems by the dextran and Ficoll tests was further confirmed by a variety of absorption analyses and by F1 tests. This study completes the systematic serological comparison of the haplotypes of the major histocompatibility complex of the rat described originally in the Ag‐B and H‐1 systems.