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GENETICS OF SUSCEPTIBILITY TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS STUDIED IN THREE RAT STRAINS
Author(s) -
Lindh J.,
Källén B.
Publication year - 1978
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1978.tb00663.x
Subject(s) - biology , backcrossing , experimental autoimmune encephalomyelitis , genetics , gene , strain (injury) , genetic predisposition , immunogenetics , immune system , anatomy
SUMMARY A genetic analysis has been performed on susceptibility to experimental autoimmune encephalomyelitis using three strains of rats: one susceptible strain (Lewis) and two nearly resistant strains (Fischer and PVG). The (LEW x F)F 1 hybrid is highly susceptible, the (LEW x PVG)F 1 hybrid nearly resistant. Backcross analysis demonstrates that susceptibility cannot be solely explained by a gene linked to the AgB complex, especially not in the Lewis‐PVG combinations. A hypothesis is presented where susceptibility is regulated by a susceptibility gene linked to the AgB complex and a resistance gene which is not linked to that complex.