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α‐N‐ACETYL‐ d ‐GALACTOSAMIYL‐ AND α‐ d ‐GALACTOSYLTRANSFERASE ACTIVITIES IN SERA OF CIS AB BLOOD GROUP INDIVIDUALS
Author(s) -
Badet J.,
Ropar C.,
Salmon C.
Publication year - 1978
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1978.tb00650.x
Subject(s) - galactosyltransferase , glycosyltransferase , enzyme , transferase , biochemistry , biosynthesis , galactosamine , galactose , homogeneous , chemistry , abo blood group system , biology , microbiology and biotechnology , genetics , physics , thermodynamics
SUMMARY Thirteen cis AB persons from five families were examined for serum glycosyltransferase activities associated with the biosynthesis of A and B blood group characters. Their transferases were generally homogeneous within one family, except for A 2 / cis AB genotypes, whose A enzyme level was similar to the A 2 normal sera, but they varied from one family to another. These activities differed quantitatively and qualitatively from A, B and AB normal sera. Studies of A transferase showed variations in the pH‐dependent curve, the effect of cofactors and the capacity of conversion of O red cells into A‐active cells. Moreover, A and B transferases behaved differently with respect to their relative levels than did AB heterozygous normal sera. The results were discussed and it was suggested that a mutation of a single enzyme transferring both galactose and N‐acetyl‐galactosamine could explain these properties.